Plots

PA_sys

X0.40007768791627_ENSG00000069188_chr17.73643905.73644104.png

mPAP

X0.409566315098446_ENSG00000069188_chr17.73643905.73644104.png

Info

SDK2 is associated to idiopathic inflammatory myopathies.
(Rothwell, Simon, et al. "Genome-wide imputation identifies novel associations and localises signals in idiopathic inflammatory myopathies." Arthritis & rheumatology 75.6 (2023): 1021-1027.)

There is a potential connection between idiopathic inflammatory myopathie and PAH.
(Sanges, Sébastien, et al. "Pulmonary arterial hypertension in idiopathic inflammatory myopathies: data from the French pulmonary hypertension registry and review of the literature." Medicine 95.39 (2016): e4911.)

NCBI Gene Summary for SDK2 Gene

The protein encoded by this gene is a member of the immunoglobulin superfamily. The protein contains two immunoglobulin domains and thirteen fibronectin type III domains. Fibronectin type III domains are present in both extracellular and intracellular proteins and tandem repeats are known to contain binding sites for DNA, heparin and the cell surface. This protein, and a homologous mouse sequence, are very similar to the Drosophila sidekick gene product but the specific function of this superfamily member is not yet known. Evidence for alternative splicing at this gene locus has been observed but the full-length nature of additional variants has not yet been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for SDK2 Gene

SDK2 (Sidekick Cell Adhesion Molecule 2) is a Protein Coding gene. Diseases associated with SDK2 include Patellar Tendinitis and Panic Disorder. Among its related pathways is Cell junction organization. An important paralog of this gene is SDK1.